![]() The standard humoral response to infection involves the early expression of IgM isotype antibodies, which matures into the expression of IgG isotype antibodies. When can the antibody response be detected in COVID-19? Though many researchers are working to develop serological assays to detect SARS-CoV-2 infection, a thorough understanding of the antibody response in COVID-19 has restricted the speed of development in this field. The use of these assays could complement RNA detection strategies, providing information on the adapted immune response to SARS-CoV-2 infection, and aiding in infection control within the clinic and communities. This increased understanding of patient antibody responses could also provide additional insight for vaccine developers in trials. Serological assays detecting antibodies to SARS-COV-2 would therefore be useful to speed diagnosis, determine the immunity period for SARS-CoV-2, and re-admit people to work following potential infection 1,2. As antibodies and protein antigens are more stable than RNA, how patient samples are transported and handled isn’t as critical for accurate detection, which reduces the number of potential false-negatives 3,4. ![]() The detection of antibodies to SARS-CoV-2 offers a more robust and simpler method for the detection of the virus. However, this has shown to yield a high number of false-negative results, is limited by requirements of extensive hands-on time from skilled workers and the need for specialist equipment, and results in longer diagnosis times 1,2. Current diagnostics for SARS-CoV-2 infection rely on the detection of the viral RNA by real-time PCR (RT-qPCR).
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